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To meet the diagnostic criteria for cEDS, a person must meet: Major criterion 1 AND major criterion 2 OR Major criterion 1 AND three or more minor criteria Major Criteria Skin hyperextensibility and atrophic scarring Generalized joint hypermobility Minor Criteria Easy bruising Soft, doughy skin Skin fragility (or traumatic splitting) Molluscoid pseudotumors Subcutaneous spheroids Hernia (or history thereof) Epicanthal folds Complications of joint hypermobility (e.g., sprains, dislocations/subluxations, pain, flexible flatfoot) Family history of a first-degree relative who meets clinical criteria Genetic testing is used to see if a person has a genetic variant that causes vEDS

doi: 10.1016/j.jconrel.2024.12.073 39 MonaliPFanSAlexJLLiangZThomasRNDebebeTet al

Waist and hip circumferences were measured at the mid-point between the lower costal margins and the level of the anterior superior iliac crest to the nearest millimetre with the participant in a relaxed, standing position using standard measuring tape

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Lu J, Vlamis-Gardikas A, Kandasamy K, Zhao R, Gustafsson TN, Engstrand L, Hoffner S, Engman L, Holmgren A